Study of the Catecholase Activity of new catalysts Based on Copper (II) and Heterocyclic Ligands

In this work, we are interested in finding new catalysts for catecholase, whose principle is based on the oxidation reaction of catechol to o-quinone. We approached synthesis threes tripod ligands pyrazole a condensation and its characterization by IR, 13C NMR, 1H NMR spectroscopy, then evaluated catalytic properties certain complexes formed situ catalyze catechols o-quinones. The aim find right models reproduce activity enzyme (catecholase), used derivatives with Copper salts. Among these complexes, complex L4/Cu(CH3COO)2 showed good combination (1ligand/2metal) MeOH reaction, speed Vmax equal 69.38 μmol.L-1.min-1 low value Km 0.019 mol.L-1. have demonstrated that nature concentration, ligand, solvent, copper salts, influenced strongly catecholase activity.